Refining the Focus: Uncoupling Inflammation and Joint Destruction CME

Ronald van Vollenhoven, MD, PhD; Josef Smolen, MD; Edward Keystone, MD
Disclosures

Uncoupling Inflammation and Joint Destruction: What Is the Relevance?
by Ronald van Vollenhoven, MD, PhD
Introduction
Uncoupling Inflammation and Joint Destruction: Early Evidence
Clinical Relevance of 'Uncoupling': The PREMIER Study

Understanding the Pathogenesis of Joint Damage: Implications for Treatment Strategies
by Josef Smolen, MD
Introduction
The Process of Joint Destruction in Rheumatoid Arthritis
The Clinical Importance of Joint Destruction
Osteoclasts and the Pathways to Joint Destruction
Interfering With Joint Damage
Mechanism
Conclusions

How Early Is Early? Applying Evidence to Achieve Optimal Outcomes in Clinical Practice
by Edward Keystone, MD
Early Use of Biologics in Rheumatoid Arthritis
ATTRACT Trial
Treating Moderate Disease Earlier With Biologics
The Benefit of Tight Control
Combination Therapy vs Monotherapy
Radiographic Outcomes

http://www.medscape.com/viewprogram/6053?src=0_nl_sm_0#2